CompleteCompositionVectorCLI For Mac

The classic genotyping approach has been based on phylogenetic analysis, starting with a multiple sequence alignment. Genotypes are then established by expert examination of phylogenetic trees.

However, such methods are suboptimal for a rapidly growing dataset, because they require significant human effort, and because they increase in computational complexity quickly with the number of sequences.

CompleteCompositionVectorCLI employs a method for genotyping which is independent of any multiple sequence alignment.

CompleteCompositionVectorCLI uses the complete composition vector algorithm to represent each sequence in the dataset as a vector derived from its constituent k-mers, and affinity propagation clustering to group the sequences into genotypes based on a distance measure over the vectors.

Our methods produce results that correlate well with expert-defined clades or genotypes, at a fraction of the computational cost of traditional phylogenetic methods.

Detailed instructions on how to install and use the CompleteCompositionVectorCLI utility on your Mac are available HERE.