Graphical sequence editing
Thanks to MacVector, you can easily read and write DNA and Protein sequences in the desired file format. What is more, the “Click Cloning” graphical interface makes it easy for you to simulate laboratory cloning experiments in order to create new molecules.
The fully functional Sequence Editor helps you edit sequences, annotations and features. Moreover, all feature locations are correctly maintained during edits while the audio function playbacks the selected residues for easier proofreading.
Topo Cloning and Gateway
Technologies provides by Invitrogen, such as Gateway, Zero Blunt and TOPO TA kits are fully supported by MacVector. Consequently, you can replicate biological manipulations and create new molecules with the correct sequences across the recombination and cloning junctions.
Auto annotation capabilities
By using MacVector, you can scan unannotated or fractionally annotated sequences against a folder on your Mac’s hard disk, let MacVector find matching features in sequences and add them to your sequence. You can use this feature to maintain a properly curated set of the desired genes and sequences.
What is more, MacVector helps you design primers from PCR or Sequencing / Hybridization probes with the helps of numerous primer design functions that include versatile scanning functions such as the Primer3 algorithm.
DNA and Protein analysis
MacVector also comes with numerous DNA analysis tools that cover anything from base composition analysis, DNA subsequence searchers, restriction enzyme searches, “Dot-Plot” comparisons between DNA:DNA and DNA:Protein sequences.
You can reverse translate protein sequences into DNA, compare them using the “Dot-Plot” analysis and scanned for Proteolytic cleavages sites, as well as amino acid sequences motifs.
Using the Internet connection you can connect to the NCBI BLAST and Entrez databases and search for DNA and protein sequences based on authors, features, keywords and download them directly from within MacVector.
Reviewed by George Popescu on April 14th, 2014
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- The graphics Symbol Editor and floating Graphics Palette have been rewritten in preparation for MacVector moving to a 64-bit architecture (due with MacVector 14.0). The other main enhancements have been aimed at better handling of Next Generation Sequencing (NGS) files, particularly with the Align To Folder and Assembler Velvet de novo assembly functionality. There has also been significant code optimization to better handle the analysis of large genomic sequences, particularly noticeable with the Pustell Matrix “dot-plot” functionality.
- Align To Reference Enhancements:
- The Align To Reference alignment algorithm and the Editor now handle alignments around a circular sequence. Note that this is only the case for the Sequence Confirmation algorithm. The cDNA Alignment algorithm still assumes the target sequence is linear.
Application descriptionMacVector is a general DNA and Protein sequence analysis, manipulation and documentation program. MacVector features a...