CoLocalizer Express helps specialists define precise locations of proteins and nucleic acids in tissues or cells in order to let them analyze the functional significance of protein-protein interactions. CoLocalizer Express is used by leading research laboratories worldwide.
CoLocalizer Express application is compatible with images produced by all major brands of confocal fluorescence microscopes, including TIFF, Zeiss LSM 4 TIFF Chunky, Zeiss LSM 4 TIFF RGB Planar, JPEG, PICT, BMP, etc.
Quantification of colocalization using CoLocalizer Express is based on calculation of the following coefficients: Pearson's correlation coefficient (Rr), overlap coefficient according to Manders (R), overlap coefficients k1 and k2, colocalization coefficients m1 and m2, and colocalization coefficients M1 and M2.
Reliability of calculation is ensured by using the background correction tool. Using this tool, pixels with intensities potentially contributing to false counts are effectively removed from the image.
NOTE: To buy CoLocalizer Express via the App Store, an Apple account is required.
· 64-bit processor
What's New in This Release: [ read full changelog ]
· Enabled sandboxing.
· Added Histogram functionality.
· Show Info window has been transformed into a panel.
· Show Info panel now always appear on top of the main application window.
· Values of the Show Info panel are now selectable.
· Show Info panel now indicates what kind of background correction was applied to the image.
· Background correction window now always appear on top of the main application window.
· Added proper types of pointers when selecting and moving scatter gram ROI.
· Added the help button to the warning about background correction step when calculating coefficients for the scatter gram ROI.
· Improved text of the background correction warning.
· Improved layout of the About Box, updated its contents.
· Improved layout of the main application window.
· Improved Mac OS X 10.8 (Mountain Lion) support.
· Now uses a crosshair cursor over the histogram.
· Fixed a bug when changes of ROI settings in the preferences were clearing selected scatter gram ROI.
· Fixed a bug when changes of ROI shapes in...