TwitterPod is Twitter client for Mac OS X. TwitterPod adoption of Core Data. So TwitterPod can store logs to database and search Twitter logs quickly like Mail.app.

TwitterPod has a search field at Top right of main window if you input keyword to that field. You can search Twitter logs incrementally.

Double click username field of column at table view. TwitterPod insert @username to message field and filter logs from username. You can reply message quickly.